SCHEMBL9599435

SCHEMBL9599435

O=c1cc(C(F)(F)F)ccn1-c1ccc(O)cc1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.43
ESR2 Q92731 2/20 0.43
CA2 P00918 1/20 0.35
SCD O00767 1/20 0.34
USP7 Q93009 1/20 0.34
CAPN1 P07384 1/20 0.34
FFAR4 Q5NUL3 3/20 0.33
ALDH1A1 P00352 2/20 0.33
PKM P14618 1/20 0.33
TRPA1 O75762 1/20 0.33
BACE1 P56817 1/20 0.33
KDM4E B2RXH2 1/20 0.33
AADAT Q8N5Z0 1/20 0.33
KIF11 P52732 1/20 0.33
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
MEN1 O00255 1/20 0.32
CYP1A2 P05177 1/20 0.32
HSP90AA1 P07900 1/20 0.32
CYP3A4 P08684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9598055 0.82 SMN1; SMN2 (0.41) CA2SCDALDH1A1PKMKDM4E
SCHEMBL9598871 0.78 ALDH1A1 (0.48) ALDH1A1KDM4EKIF11LMNAMAPT
SCHEMBL12333513 0.76 HSP90AA1 (0.43) CA2SCDALDH1A1PKMKDM4E
SCHEMBL9598659 0.75 ALDH1A1 (0.43) ALDH1A1KDM4ELMNAGAAMEN1
SCHEMBL9774765 0.74 CA2 (0.37) CA2SCDLMNAGAAMAPT
SCHEMBL7698169 0.73 TRPV4 (0.38) ALDH1A1KDM4EGAA
SCHEMBL10679727 0.73 CA2 (0.36) CA2SCDLMNAGAA
SCHEMBL10059399 0.72 MCHR1 (0.43) CA2ALDH1A1CYP3A4CYP2C19
SCHEMBL9774979 0.72 MEN1 (0.36) CA2SCDUSP7ALDH1A1LMNA
SCHEMBL9774914 0.71 CA2 (0.34) CA2SCDTRPA1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5238906-A Herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-08-24 US disclosed
EP-0488220-A2 Pyridone derivatives, and their production and use SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1992-06-03 EP disclosed