Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.67 |
| ▸ | HTR3A | P46098 | 8/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9600934 | 0.83 | HTR1A (0.69) | HTR1AHTR3AHTR7HRH1HRH3 | |
| SCHEMBL3676077 | 0.78 | HTR1A (0.95) | HTR1AHTR3AHTR7SLC6A4HRH3 | |
| SCHEMBL9539310 | 0.77 | DRD2 (0.64) | HTR1ADRD2 | |
| SCHEMBL9822816 | 0.77 | — | — | |
| SCHEMBL10556971 | 0.76 | HTR1A (0.55) | HTR1AHRH3 | |
| SCHEMBL10465797 | 0.75 | HTR1A (0.76) | HTR1AHTR7SLC6A4DRD2DRD3 | |
| SCHEMBL9822899 | 0.74 | DRD2 (0.67) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL9602546 | 0.74 | HTR1A (0.67) | HTR1AHTR3AHTR7HRH1HRH3 | |
| SCHEMBL10555981 | 0.74 | HTR1A (0.48) | HTR1AHTR3AHTR7HRH1DRD2 | |
| SCHEMBL3679755 | 0.72 | HTR1A (0.65) | HTR1AHTR3AHTR7HRH1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4797488-A | N-((4-(PHENYL OR HETEROCYCLIC)PIPERAZIN-1-YL)ALKYL)-1,5-METHANOCYCLOPENT(D)AZEPINE-2,4 -DIONES; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-10 | — | — | US | claimed |
| WO-1988007529-A1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | claimed |
| EP-0286263-B1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-15 | — | — | EP | disclosed |