Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9603083 | 1.00 | MCHR1 (0.39) | MCHR1HRH3KMT2AMEN1LMNA | |
| SCHEMBL9867236 | 0.88 | MCHR1 (0.44) | MCHR1HRH3KMT2AMEN1LMNA | |
| Fumaric Acid SCHEMBL9602362 | 0.85 | HRH3 (0.37) | HRH3KMT2AMEN1ALDH1A1GAA | |
| Fumaric Acid SCHEMBL9602356 | 0.85 | HRH3 (0.37) | HRH3KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9867705 | 0.84 | MCHR1 (0.41) | MCHR1HRH3KMT2AMEN1RECQL | |
| SCHEMBL9866420 | 0.84 | MCHR1 (0.43) | MCHR1HRH3KMT2AMEN1LMNA | |
| SCHEMBL9865646 | 0.83 | MCHR1 (0.40) | MCHR1HRH3KMT2AMEN1ALDH1A1 | |
| SCHEMBL9867683 | 0.83 | ALDH1A1 (0.41) | MCHR1HRH3KMT2AMEN1LMNA | |
| SCHEMBL9866266 | 0.83 | MCHR1 (0.42) | MCHR1HRH3KMT2AMEN1LMNA | |
| SCHEMBL9866270 | 0.83 | MCHR1 (0.42) | MCHR1HRH3KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |