Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 8/20 | 0.44 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10445064 | 1.00 | MAOB (0.44) | MAOBMAOAPOLBL3MBTL1BCHE | |
| Fumaric Acid SCHEMBL9602434 | 0.84 | KMT2A (0.42) | MAOBPOLBL3MBTL1BCHEACHE | |
| Fumaric Acid SCHEMBL9602442 | 0.84 | KMT2A (0.42) | MAOBPOLBL3MBTL1BCHEACHE | |
| SCHEMBL9865738 | 0.79 | TOP1 (0.38) | MAOBMAOABCHEACHEPDE5A | |
| Fumaric Acid SCHEMBL9865899 | 0.77 | ACHE (0.38) | POLBL3MBTL1ACHECACNA1BALDH1A1 | |
| Maleic Acid SCHEMBL9865891 | 0.77 | ACHE (0.38) | POLBL3MBTL1ACHECACNA1BALDH1A1 | |
| SCHEMBL9601582 | 0.76 | MAPK14 (0.40) | MAOBCACNA1BALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL10445212 | 0.75 | KMT2A (0.40) | POLBL3MBTL1ALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL9865749 | 0.75 | KMT2A (0.40) | POLBL3MBTL1ALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL9867764 | 0.74 | L3MBTL1 (0.40) | MAOBMAOAPOLBL3MBTL1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |