Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.58 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 10/20 | 0.58 |
| ▸ | HTR2A | P28223 | 9/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.58 |
| ▸ | HRH1 | P35367 | 4/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9601481 | 0.81 | DRD3 (0.54) | DRD3HTR2ADRD2ADRA1AHRH1 | |
| Fumaric Acid SCHEMBL9601489 | 0.81 | DRD3 (0.54) | DRD3HTR2ADRD2ADRA1AHRH1 | |
| Hydrochloric Acid SCHEMBL9601527 | 0.81 | DRD3 (0.54) | DRD3HTR2ADRD2ADRA1AHRH1 | |
| SCHEMBL9602299 | 0.78 | HTR2A (0.52) | DRD3HTR2ADRD2ADRA1AHRH1 | |
| Fumaric Acid SCHEMBL7860253 | 0.78 | HTR1A (0.61) | DRD3HTR2ADRD2HRH1KCNH2 | |
| Fumaric Acid SCHEMBL7860254 | 0.78 | HTR1A (0.61) | DRD3HTR2ADRD2HRH1KCNH2 | |
| Hydrochloric Acid SCHEMBL9603058 | 0.76 | DRD2 (0.79) | DRD3HTR2ADRD2HRH1SLC6A3 | |
| SCHEMBL6525544 | 0.75 | KCNH2 (0.63) | DRD3HTR2ADRD2KCNH2CYP3A4 | |
| Oxalic Acid SCHEMBL9602668 | 0.75 | DRD3 (0.50) | DRD3HTR2ADRD2ADRA1AHRH1 | |
| SCHEMBL9601301 | 0.74 | DRD2 (0.56) | DRD3HTR2ADRD2ADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308476-B1 | BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION | Kabi Pharmacia AB (SE) | 1993-02-03 | — | — | EP | disclosed |
| US-4937245-A | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | FEX TOMAS (SE) | 1990-06-26 | — | — | US | disclosed |