Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 11/20 | 0.61 |
| ▸ | HTR2A | P28223 | 10/20 | 0.61 |
| ▸ | DRD3 | P35462 | 9/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 6/20 | 0.56 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6525545 | 0.82 | KCNH2 (0.71) | KCNH2HTR1AHTR2ADRD3HTR3E | |
| Hydrochloric Acid SCHEMBL6526782 | 0.81 | KCNH2 (0.70) | KCNH2HTR1AHTR2ADRD3HTR3E | |
| SCHEMBL3153996 | 0.80 | HTR3E (0.66) | KCNH2HTR1AHTR2ADRD3HTR3E | |
| SCHEMBL3674700 | 0.78 | HTR1A (0.72) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL4519830 | 0.77 | KCNH2 (1.00) | KCNH2HTR1AHTR2ADRD3HTR3E | |
| Quinaldine SCHEMBL3408896 | 0.77 | KCNH2 (0.60) | KCNH2HTR1AHTR2ADRD3HTR3A | |
| SCHEMBL4522254 | 0.77 | DRD3 (1.00) | KCNH2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL25695217 | 0.75 | HTR3E (0.67) | KCNH2HTR1AHTR2ADRD3HTR3E | |
| SCHEMBL13711981 | 0.75 | KCNH2 (0.87) | KCNH2HTR1AHTR2ADRD3HTR3E | |
| SCHEMBL4546510 | 0.75 | HTR1A (0.78) | KCNH2HTR1AHTR2ADRD3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2011-03-10 | — | — | US | claimed |
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | HTR3A, HTR2A, HTR5A | KCNH2 828/4885HTR1A 5/4885HTR2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.