Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicyclol SCHEMBL9600725 | 0.86 | TARBP2 (0.43) | TARBP2HSD17B10HPGDKDM4EALDH1A1 | |
| Bicyclol SCHEMBL29380248 | 0.86 | TARBP2 (0.43) | TARBP2HSD17B10HPGDKDM4EALDH1A1 | |
| SCHEMBL9601730 | 0.79 | KMT2A (0.45) | TDP1ALDH1A1GAAMAPK1MAPT | |
| SCHEMBL9602401 | 0.78 | HSD17B10 (0.40) | HSD17B10ALDH1A1GAAMAPK1MAPT | |
| Bifendate SCHEMBL30788692 | 0.78 | TARBP2 (0.48) | TARBP2HSD17B10HPGDKDM4EALDH1A1 | |
| Bifendate SCHEMBL896166 | 0.78 | TARBP2 (0.48) | TARBP2HSD17B10HPGDKDM4EALDH1A1 | |
| Bifendate SCHEMBL29516235 | 0.78 | TARBP2 (0.48) | TARBP2HSD17B10HPGDKDM4EALDH1A1 | |
| SCHEMBL23438996 | 0.77 | TARBP2 (0.41) | TARBP2HSD17B10HPGDKDM4EALDH1A1 | |
| SCHEMBL21600700 | 0.76 | TARBP2 (0.41) | TARBP2HSD17B10HPGDKDM4EALDH1A1 | |
| SCHEMBL9603034 | 0.75 | CYP3A4 (0.43) | KDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353358-B1 | BIS(METHYLENEDIOXY)BIPHENYL COMPOUNDS | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1993-08-18 | — | — | EP | disclosed |
| EP-0353358-A1 | Bis(methylenedioxy)biphenyl compounds | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1990-02-07 | — | — | EP | disclosed |
| US-4868207-A | Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-19 | — | — | US | disclosed |