Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602401 | 0.88 | HSD17B10 (0.40) | GAAMAPTALDH1A1CYP3A4MAPK1 | |
| Bicyclol SCHEMBL9600725 | 0.84 | TARBP2 (0.43) | KMT2AMEN1HTTALDH1A1CYP3A4 | |
| SCHEMBL9603034 | 0.80 | CYP3A4 (0.43) | KMT2AMEN1MAPTALDH1A1CYP3A4 | |
| SCHEMBL9602591 | 0.79 | TARBP2 (0.37) | TDP1GAAMAPTALDH1A1MAPK1 | |
| Bifendate SCHEMBL896166 | 0.76 | TARBP2 (0.48) | KMT2AMEN1HTTALDH1A1CYP3A4 | |
| SCHEMBL9327972 | 0.75 | LMNA (0.42) | KMT2ATSHRL3MBTL1MEN1MAPT | |
| Bifendate SCHEMBL6318235 | 0.75 | RXFP1 (0.42) | KMT2ATSHRTDP1MEN1GAA | |
| SCHEMBL23438996 | 0.75 | TARBP2 (0.41) | KMT2ATSHRMEN1GAAMAPT | |
| SCHEMBL9328127 | 0.75 | NPSR1 (0.41) | KMT2AMEN1GAAMAPTCYP3A4 | |
| SCHEMBL9329585 | 0.74 | LMNA (0.39) | KMT2ATSHRTDP1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353358-B1 | BIS(METHYLENEDIOXY)BIPHENYL COMPOUNDS | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1993-08-18 | — | — | EP | disclosed |
| EP-0353358-A1 | Bis(methylenedioxy)biphenyl compounds | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1990-02-07 | — | — | EP | disclosed |
| US-4868207-A | Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-19 | — | — | US | disclosed |