Bicyclol

Bicyclol

SCHEMBL9600725

COC(=O)c1cc(OC)c2c(c1-c1c(CO)cc(OC)c3c1OCO3)OCO2

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TARBP2 Q15633 2/20 0.43
CYP3A4 P08684 2/20 0.42
ALOX15 P16050 1/20 0.42
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 3/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
PKM P14618 1/20 0.39
POLB P06746 2/20 0.39
HTT P42858 1/20 0.38
HPGD P15428 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicyclol SCHEMBL29380248 1.00 TARBP2 (0.43) TARBP2CYP3A4ALOX15KDM4EALDH1A1
Bifendate SCHEMBL896166 0.92 TARBP2 (0.48) TARBP2CYP3A4ALOX15KDM4EALDH1A1
Bifendate SCHEMBL30788692 0.92 TARBP2 (0.48) TARBP2CYP3A4ALOX15KDM4EALDH1A1
Bifendate SCHEMBL29516235 0.92 TARBP2 (0.48) TARBP2CYP3A4ALOX15KDM4EALDH1A1
SCHEMBL23438996 0.90 TARBP2 (0.41) TARBP2CYP3A4ALOX15KDM4EALDH1A1
SCHEMBL21600700 0.88 TARBP2 (0.41) TARBP2CYP3A4ALOX15KDM4EALDH1A1
SCHEMBL9602401 0.88 HSD17B10 (0.40) CYP3A4ALOX15ALDH1A1HSD17B10
SCHEMBL9603034 0.88 CYP3A4 (0.43) CYP3A4ALOX15KDM4EALDH1A1MEN1
SCHEMBL23438995 0.87 PDCD1 (0.40) TARBP2CYP3A4ALOX15KDM4EMEN1
SCHEMBL9602591 0.86 TARBP2 (0.37) TARBP2KDM4EALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2048574-A None JP disclosed
JP-3153680-A None JP disclosed
JP-63192771-A None JP disclosed
US-20230158161-A1 DRUG DELIVERY SYSTEMS COMPRISING AN INTRAOCULAR PRESSURE LOWERING AGENT, A NEUROTROPHIC AGENT, A C-TYPE NATRIURETIC PEPTIDE, A NATRIURETIC PEPTIDE RECEPTOR-B, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR OR A FAS-LIGAND INHIBITOR FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION CELLA THERAPEUTICS, LLC 2023-05-25 US disclosed
US-20230002343-A1 LEFT-HANDED BICYCLIC MORPHOLINE AND SALT THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2023-01-05 US disclosed
US-11147855-B2 Methods for treating glaucoma or ocular hypertension comprising delivery of prostaglandins to the vitreous humour CELLA THERAPEUTICS, LLC (US) 2021-10-19 US disclosed
WO-2021103749-A1 LEFT-HANDED BICYCLIC MORPHOLINE AND SALT THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATION 中国医学科学院药物研究所 2021-06-03 WO disclosed
US-20210121534-A1 SUSTAINED-RELEASE DRUG DELIVERY SYSTEMS COMPRISING AN INTRAOCULAR PRESSURE LOWERING AGENT, A CNP COMPOUND, AN NPR-B COMPOUND, A TIE-2 AGONIST, OR NEUROTROPHIC AGENT FOR USE FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION CELLA THERAPEUTICS, LLC 2021-04-29 US disclosed
US-20210100907-A1 DRUG DELIVERY SYSTEMS COMPRISING A NEUROTROPHIC AGENT, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR (FAS) OR FAS LIGAND (FASL) INHIBITOR, A TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) OR TNF RECEPTOR INHIBITOR, A MITOCHONDRIAL PEPTIDE, AN OLIGONUCLEOTIDE, A CHEMOKINE INHIBITOR, OR A CYSTEINE-ASPARTIC PROTEASE INHIBITOR CELLA THERAPEUTICS, LLC 2021-04-08 US disclosed
US-20200108117-A1 DRUG DELIVERY SYSTEMS COMPRISING AN INTRAOCULAR PRESSURE LOWERING AGENT, A NEUROTROPHIC AGENT, A C-TYPE NATRIURETIC PEPTIDE, A NATRIURETIC PEPTIDE RECEPTOR-B, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR OR A FAS-LIGAND INHIBITOR FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION CELLA THERAPEUTICS, LLC 2020-04-09 US disclosed
EP-0353358-B1 BIS(METHYLENEDIOXY)BIPHENYL COMPOUNDS TAISHO PHARMACEUTICAL CO. LTD (JP) 1993-08-18 EP disclosed
JP-H03153680-A BIPHENYL COMPOUND AND PROCESS FOR PRODUCTION OF THE SAME ZHONGGUO YIXUEKEXUEYUAN YAOWO YANJIUSUO 1991-07-01 JP disclosed
JP-H0248574-A BIS(METHYLENEDIOXY)BIPHENYL COMPOUND CHUNGUO IISHE KUUSHUEYUANYAOU IENJUSUO 1990-02-19 JP disclosed
EP-0353358-A1 Bis(methylenedioxy)biphenyl compounds TAISHO PHARMACEUTICAL CO. LTD (JP) 1990-02-07 EP disclosed
US-4868207-A Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases TAISHO PHARMACEUTICAL CO., LTD. (JP) 1989-09-19 US disclosed
JP-S63192771-A 2,3,2',3'-BIS(METHYLENEDIOXY)BIPHENYL COMPOUND, PRODUCTION THEREOF AND REMEDY FOR LIVER DISEASE CONTAINING SAID COMPOUND ISUKURA SANGYO KK 1988-08-10 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210100907-A1 DRUG DELIVERY SYSTEMS COMPRISING A NEUROTROPHIC AGENT, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR (FAS) OR FAS LIGAND (FASL) INHIBITOR, A TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) OR TNF RECEPTOR INHIBITOR, A MITOCHONDRIAL PEPTIDE, AN OLIGONUCLEOTIDE, A CHEMOKINE INHIBITOR, OR A CYSTEINE-ASPARTIC PROTEASE INHIBITOR NGFR, TNFRSF1A, TNFSF10 TARBP2 2224/4885CYP3A4 4701/4885ALOX15 1245/4885
US-20230158161-A1 DRUG DELIVERY SYSTEMS COMPRISING AN INTRAOCULAR PRESSURE LOWERING AGENT, A NEUROTROPHIC AGENT, A C-TYPE NATRIURETIC PEPTIDE, A NATRIURETIC PEPTIDE RECEPTOR-B, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR OR A FAS-LIGAND INHIBITOR FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION NPR1, NPR3, NTSR2 TARBP2 2930/4885CYP3A4 4709/4885ALOX15 2617/4885
US-20230002343-A1 LEFT-HANDED BICYCLIC MORPHOLINE AND SALT THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE SLC10A1, CYP7B1, ALG3 TARBP2 3291/4885CYP3A4 144/4885ALOX15 594/4885
US-20210121534-A1 SUSTAINED-RELEASE DRUG DELIVERY SYSTEMS COMPRISING AN INTRAOCULAR PRESSURE LOWERING AGENT, A CNP COMPOUND, AN NPR-B COMPOUND, A TIE-2 AGONIST, OR NEUROTROPHIC AGENT FOR USE FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION NPR1, NGFR, NTSR2 TARBP2 3500/4885CYP3A4 4714/4885ALOX15 2355/4885
US-20200108117-A1 DRUG DELIVERY SYSTEMS COMPRISING AN INTRAOCULAR PRESSURE LOWERING AGENT, A NEUROTROPHIC AGENT, A C-TYPE NATRIURETIC PEPTIDE, A NATRIURETIC PEPTIDE RECEPTOR-B, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR OR A FAS-LIGAND INHIBITOR FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION NPR1, NPR3, NTSR2 TARBP2 2930/4885CYP3A4 4709/4885ALOX15 2617/4885
US-11147855-B2 Methods for treating glaucoma or ocular hypertension comprising delivery of prostaglandins to the vitreous humour NPR1, PGF, NPR3 TARBP2 4175/4885CYP3A4 4686/4885ALOX15 647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.