Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602962 | 0.89 | HRH3 (0.36) | HRH3KDRCA12CA1CA2 | |
| SCHEMBL9867229 | 0.83 | TOP1 (0.40) | TOP1HRH3MAPTKDM4ENPC1 | |
| SCHEMBL9602979 | 0.83 | MCHR1 (0.43) | TOP1HRH3KDRCA12CA1 | |
| SCHEMBL9865898 | 0.80 | CA12 (0.35) | HRH3KDRCA12CA1CA2 | |
| Iodide SCHEMBL10445020 | 0.79 | ALDH1A1 (0.35) | HRH3KDRCA12CA1CA2 | |
| SCHEMBL9866081 | 0.78 | HRH3 (0.33) | HRH3CA12CA1CA2CA9 | |
| SCHEMBL9603117 | 0.77 | CDK4 (0.39) | HTTALDH1A1 | |
| SCHEMBL9602093 | 0.77 | HRH3 (0.39) | TOP1HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL10560058 | 0.77 | MMP12 (0.44) | CA12CA1CA2CA9MAPT | |
| SCHEMBL9866493 | 0.76 | HRH3 (0.41) | TOP1HRH3MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |