Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9603224 | 0.92 | DRD2 (0.36) | DRD2HTR1AHTR2AHTR7DRD3 | |
| SCHEMBL9602330 | 0.92 | ESR1 (0.37) | DRD2CNR2LMNASIGMAR1ESR1 | |
| SCHEMBL9602809 | 0.84 | DRD2 (0.34) | DRD2HTR1AHTR2ADRD3KCNH2 | |
| SCHEMBL9602515 | 0.84 | ALDH1A1 (0.33) | DRD2HTR2ALMNA | |
| SCHEMBL9602555 | 0.84 | ALDH1A1 (0.34) | DRD2HTR2AMAPK14LMNA | |
| Hydrochloric Acid SCHEMBL9602446 | 0.82 | MAPK14 (0.46) | DRD2HTR1AHTR2AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL9602451 | 0.82 | MAPK14 (0.46) | DRD2HTR1AHTR2AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL9602310 | 0.82 | S1PR1 (0.33) | DRD2HTR2ALMNA | |
| SCHEMBL9601947 | 0.81 | ADRB1 (0.39) | TDP1LMNA | |
| SCHEMBL9601365 | 0.80 | MAPK14 (0.35) | DRD2HTR1AHTR2AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |