Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9603224 | 0.93 | DRD2 (0.36) | SIGMAR1DRD2HRH3MAPT | |
| SCHEMBL9602850 | 0.92 | DRD2 (0.35) | ESR1CNR2SIGMAR1DRD2LMNA | |
| SCHEMBL9602809 | 0.87 | DRD2 (0.34) | CNR2DRD2HRH3KDM4EALDH1A1 | |
| SCHEMBL9602515 | 0.86 | ALDH1A1 (0.33) | DRD2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL9602555 | 0.86 | ALDH1A1 (0.34) | DRD2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL9866075 | 0.85 | HTR1A (0.37) | ESR1ESR2DRD2HRH3 | |
| SCHEMBL9601947 | 0.84 | ADRB1 (0.39) | KDM4ELMNAMAPT | |
| Hydrochloric Acid SCHEMBL9602310 | 0.84 | S1PR1 (0.33) | DRD2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL9601493 | 0.81 | MAPT (0.40) | DRD2KDM4EALDH1A1LMNAGAA | |
| Fumaric Acid SCHEMBL9603164 | 0.80 | KDM4E (0.35) | DRD2KDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |