Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9603160 | 0.94 | KDM4E (0.35) | ALDH1A1KDM4ELMNAGAAMAPT | |
| Fumaric Acid SCHEMBL9603164 | 0.94 | KDM4E (0.35) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL9602191 | 0.92 | DRD2 (0.32) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL9867304 | 0.90 | MAOA (0.35) | GAAACHETOP1 | |
| Hydrochloric Acid SCHEMBL9602310 | 0.89 | S1PR1 (0.33) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL9602809 | 0.88 | DRD2 (0.34) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL9602555 | 0.88 | ALDH1A1 (0.34) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL9602330 | 0.86 | ESR1 (0.37) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL9603224 | 0.86 | DRD2 (0.36) | MAPTDRD2HTR2A | |
| SCHEMBL9605374 | 0.85 | XIAP (0.33) | ALDH1A1KDM4EDRD2HTR2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |