Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 10/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.42 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9602903 | 1.00 | HRH3 (0.44) | HRH3KCNH2MAPK14HRH1POLB | |
| Maleic Acid SCHEMBL9865891 | 0.82 | ACHE (0.38) | HRH3MAPK14POLBMAPTACHE | |
| Fumaric Acid SCHEMBL9865899 | 0.82 | ACHE (0.38) | HRH3MAPK14POLBMAPTACHE | |
| SCHEMBL9602830 | 0.82 | HRH3 (0.48) | HRH3KCNH2HTR1AACHE | |
| Hydrochloric Acid SCHEMBL9866019 | 0.80 | DRD2 (0.44) | HRH3MAPK14 | |
| Hydrochloric Acid SCHEMBL9866011 | 0.80 | DRD2 (0.44) | HRH3MAPK14 | |
| Fumaric Acid SCHEMBL9868348 | 0.79 | L3MBTL1 (0.37) | HRH3MAPK14POLBMAPTACHE | |
| Fumaric Acid SCHEMBL9601552 | 0.79 | L3MBTL1 (0.37) | HRH3MAPK14POLBMAPTACHE | |
| SCHEMBL9601558 | 0.78 | MAOB (0.46) | HRH3HTR1AACHE | |
| SCHEMBL10365856 | 0.76 | APP (0.44) | POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |