Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.39 |
| ▸ | ALPI | P09923 | 2/20 | 0.38 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20777878 | 0.83 | ALDH1A1 (0.43) | CA2CA9CA12CA1CA7 | |
| SCHEMBL20777832 | 0.79 | KMT2A (0.39) | POLBKMT2A | |
| SCHEMBL20777728 | 0.78 | CA2 (0.36) | CA2CA9CA12CA1CA7 | |
| SCHEMBL20777563 | 0.70 | ELANE (0.40) | KDM4EMAPTPOLBSLC40A1ALDH1A1 | |
| SCHEMBL9606078 | 0.70 | CHEK1 (0.44) | CA2CA9CA12CA1CA7 | |
| SCHEMBL9604292 | 0.70 | CA2 (0.36) | CA2CA9CA12CA1CA7 | |
| SCHEMBL20777795 | 0.69 | CFTR (0.43) | CA2CA1KDM4EMAPTSLC40A1 | |
| SCHEMBL5186168 | 0.68 | CA12 (0.63) | CA2CA9CA12CA1CA7 | |
| SCHEMBL6720672 | 0.67 | PTGES (0.57) | CA2CA9CA12CA1CA7 | |
| SCHEMBL20773655 | 0.66 | GABRA2 (0.43) | CA2CA9CA12CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021171-A1 | USE OF 2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES FOR PREPARING NMDA/AMPA RECEPTOR ANTAGONIST DRUGS, NOVEL PRODUCTS, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |