Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20777728 | 0.88 | CA2 (0.36) | CA2CA12CA4CA7CA9 | |
| SCHEMBL24086549 | 0.73 | CHEK1 (0.44) | CA2CA12CA4CA7CA9 | |
| SCHEMBL9603417 | 0.70 | CA2 (0.46) | CA2CA12CA4CA7CA9 | |
| SCHEMBL20773655 | 0.69 | GABRA2 (0.43) | CA2CA12CA7CA9CA1 | |
| SCHEMBL24086559 | 0.68 | RAB9A (0.41) | CA2CA12CA9CA1MMP2 | |
| SCHEMBL6237565 | 0.67 | CA2 (0.31) | CA2CA12CA4CA7CA9 | |
| SCHEMBL20773610 | 0.67 | SLC16A3 (0.35) | — | |
| SCHEMBL20777651 | 0.65 | GABRA1 (0.33) | CA2CA1 | |
| SCHEMBL24086527 | 0.65 | CNR2 (0.37) | — | |
| SCHEMBL20773736 | 0.65 | RPS6KA3 (0.36) | TPMTGPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021171-A1 | USE OF 2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES FOR PREPARING NMDA/AMPA RECEPTOR ANTAGONIST DRUGS, NOVEL PRODUCTS, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |