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Sugi Predict / Compounds / SCHEMBL9604470

SCHEMBL9604470

SCHEMBL9604470

CC1C(COC(=O)c2ccccc2)OC(OC2C(COC(=O)c3ccccc3)OC(OCCCCCCCCC(=O)O)C(C)C2C)C(C)C1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.36
▸ TNF P01375 2/20 0.36
▸ PTPN1 P18031 2/20 0.34
▸ POLB P06746 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ USP2 O75604 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ ACP1 P24666 1/20 0.34
▸ CDC25B P30305 1/20 0.34
▸ PPARA Q07869 1/20 0.34
▸ TBXA2R P21731 2/20 0.33
▸ HDAC3 O15379 1/20 0.33
▸ HDAC4 P56524 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC7 Q8WUI4 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33
▸ HDAC10 Q969S8 1/20 0.33
▸ HDAC11 Q96DB2 1/20 0.33
▸ HDAC8 Q9BY41 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15829785 0.92 TDP1 (0.43) ALDH1A1TDP1PTPN1POLBACP1
SCHEMBL9604626 0.92 TDP1 (0.43) ALDH1A1TDP1PTPN1POLBACP1
SCHEMBL9604456 0.92 TDP1 (0.43) ALDH1A1TDP1PTPN1POLBACP1
SCHEMBL19767543 0.89 USP2 (0.42) ALDH1A1TDP1TNFPTPN1POLB
SCHEMBL18349835 0.88 USP2 (0.44) ALDH1A1TDP1TNFPTPN1POLB
SCHEMBL9604606 0.88 ALDH1A1 (0.35) ALDH1A1TDP1TNFPTPN1POLB
SCHEMBL9604595 0.88 LMNA (0.35) ALDH1A1TDP1TNFPTPN1POLB
SCHEMBL19473213 0.87 MEN1 (0.39) ALDH1A1TDP1TNFPTPN1POLB
SCHEMBL16682385 0.86 PTPN1 (0.40) ALDH1A1TDP1TNFPTPN1POLB
SCHEMBL16299273 0.85 ANTXR2 (0.43) PTPN1POLBMEN1USP2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11666653-B2 Carbohydrate conjugates as delivery agents for oligonucleotides ALNYLAM PHARMACEUTICALS, INC. (US) 2023-06-06 — — US disclosed
US-9814777-B2 Targeting lipids ARBUTUS BIOPHARMA CORPORATION (CA) 2017-11-14 — — US disclosed
US-20160375137-A9 TARGETING LIPIDS TEKMIRA PHARMACEUTICALS CORPORATION (CA) 2016-12-29 — — US disclosed
US-9370582-B2 Carbohydrate conjugates as delivery agents for oligonucleotides ALNYLAM PHARMACEUTICALS, INC. (US) 2016-06-21 — — US disclosed
US-9370581-B2 Carbohydrate conjugates as delivery agents for oligonucleotides ALNYLAM PHARMACEUTICALS, INC. (US) 2016-06-21 — — US disclosed
US-9352048-B2 Carbohydrate conjugates as delivery agents for oligonucleotides ALNYLAM PHARMACEUTICALS, INC. (US) 2016-05-31 — — US disclosed
US-9290760-B2 Modified iRNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2016-03-22 — — US disclosed
US-20150119444-A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides BANK OF AMERICA, N.A. 2015-04-30 — — US disclosed
US-20150119445-A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides BANK OF AMERICA, N.A. 2015-04-30 — — US disclosed
US-20150011615-A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides BANK OF AMERICA, N.A. 2015-01-08 — — US disclosed
US-8828956-B2 Carbohydrate conjugates as delivery agents for oligonucleotides ALNYLAM PHARMACEUTICALS, INC. (US) 2014-09-09 — — US disclosed
US-20140179761-A1 TARGETING LIPIDS TEKMIRA PHARMACEUTICALS CORPORATION (CA) 2014-06-26 — — US disclosed
US-20130178512-A1 CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC (US) 2013-07-11 — — US disclosed
US-8450467-B2 Carbohydrate conjugates as delivery agents for oligonucleotides ALNYLAM PHARMACEUTICALS, INC. (US) 2013-05-28 — — US disclosed
US-20120136042-A1 CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC (US) 2012-05-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130178512-A1 CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES LPXN, ZYX, OSTC ALDH1A1 4231/4885TDP1 3615/4885TNF 3986/4885
US-20150119445-A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides LPXN, ZYX, OSTC ALDH1A1 4381/4885TDP1 3569/4885TNF 4100/4885
US-20140179761-A1 TARGETING LIPIDS LY96, ABHD10, APOB ALDH1A1 1600/4885TDP1 2507/4885TNF 3998/4885
US-11666653-B2 Carbohydrate conjugates as delivery agents for oligonucleotides HAVCR2, B3GAT3, CSGALNACT1 ALDH1A1 3484/4885TDP1 4305/4885TNF 4341/4885
US-20150011615-A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides LPXN, ZYX, OSTC ALDH1A1 4251/4885TDP1 3621/4885TNF 3975/4885
US-20150119444-A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides LPXN, ZYX, OSTC ALDH1A1 4251/4885TDP1 3621/4885TNF 3975/4885
US-20120136042-A1 CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES LPXN, ZYX, OSTC ALDH1A1 4231/4885TDP1 3615/4885TNF 3986/4885
US-20160375137-A9 TARGETING LIPIDS LY96, ABHD10, APOB ALDH1A1 1600/4885TDP1 2507/4885TNF 3998/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.