SCHEMBL960647

SCHEMBL960647

Cc1ccc(O)c(-c2cc(-c3ccccc3)[nH]n2)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 11/20 0.72
MAPT P10636 11/20 0.72
ALOX15 P16050 9/20 0.72
KMT2A Q03164 9/20 0.72
MEN1 O00255 8/20 0.72
USP2 O75604 3/20 0.72
SMN1; SMN2 Q16637 6/20 0.69
NPSR1 Q6W5P4 5/20 0.69
CASP3 P42574 3/20 0.69
SENP8 Q96LD8 3/20 0.69
SENP7 Q9BQF6 3/20 0.69
SENP6 Q9GZR1 3/20 0.69
POLB P06746 2/20 0.69
RAB9A P51151 8/20 0.62
NPC1 O15118 5/20 0.62
HSP90AA1 P07900 2/20 0.62
LMNA P02545 5/20 0.62
TP53 P04637 3/20 0.58
GLA P06280 2/20 0.58
L3MBTL1 Q9Y468 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10357439 0.91 KMT2A (0.68) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL9911652 0.88 RAB9A (0.74) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL10357789 0.86 KMT2A (0.69) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL10357348 0.86 ALOX15 (0.67) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL7998301 0.85 MAPT (0.81) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL3594441 0.85 MAPT (0.61) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL10358110 0.84 MAPT (1.00) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL10358038 0.84 KMT2A (0.79) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL10357743 0.83 KMT2A (0.59) HPGDMAPTALOX15KMT2AMEN1
SCHEMBL10358277 0.83 MEN1 (0.83) HPGDMAPTALOX15KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3359126-B1 ALGINATE OLIGOMERS FOR THE TREATMENT OR PREVENTION OF MICROBIAL OVERGROWTH IN THE INTESTINAL TRACT ALGIPHARMA AS (NO) 2024-04-17 EP claimed
US-11759467-B2 Treatment VERONA PHARMA PLC (GB) 2023-09-19 US claimed
US-11352400-B2 PI3K gamma inhibitor peptide for treatment of respiratory system diseases KITHER BIOTECH SRL (IT) 2022-06-07 US claimed
CN-113563451-A Novel PI3K gamma inhibitor peptides for the treatment of respiratory diseases 凯思生物技术公司 2021-10-29 CN claimed
CN-107406488-B Novel PI3K gamma inhibitor peptides for the treatment of respiratory diseases 凯思生物技术公司 2021-08-31 CN claimed
US-20210106585-A1 NEW TREATMENT VERONA PHARMA LIMITED (GB) 2021-04-15 US claimed
US-20200317740-A1 NOVEL PI3K GAMMA INHIBITOR PEPTIDE FOR TREATMENT OF RESPIRATORY SYSTEM DISEASES KITHER BIOTECH SRL (IT) 2020-10-08 US claimed
US-10730921-B2 PI3Kγ inhibitor peptide for treatment of respiratory system diseases KITHER BIOTECH S.R.L. (IT) 2020-08-04 US claimed
US-20200206198-A1 CFTR CHANNEL ACTIVATOR FOR USE IN THE TREATMENT AND/OR PREVENTION OF GLUTEN SENSITIVITY CONDITIONS MAIURI LUIGI (IT) 2020-07-02 US claimed
EP-3658136-A1 CFTR CHANNEL ACTIVATOR FOR USE IN THE TREATMENT AND/OR PREVENTION OF GLUTEN SENSITIVITY CONDITIONS Raia, Valeria (IT) 2020-06-03 EP claimed
WO-2019020663-A1 CFTR CHANNEL ACTIVATOR FOR USE IN THE TREATMENT AND/OR PREVENTION OF GLUTEN SENSITIVITY CONDITIONS MAIURI LUIGI (IT) 2019-01-31 WO claimed
US-20180086798-A1 NOVEL PI3K GAMMA INHIBITOR PEPTIDE FOR TREATMENT OF RESPIRATORY SYSTEM DISEASES KITHER BIOTECH SRL (IT) 2018-03-29 US claimed
US-20180055873-A1 USE OF ALGINATE OLIGOMERS AND CFTR MODULATORS IN THE TREATMENT OF CONDITIONS ASSOCIATED WITH CFTR DYSFUNCTION ALGIPHARMA AS (NO) 2018-03-01 US claimed
EP-3273995-A1 USE OF ALGINATE OLIGOMERS AND CFTR MODULATORS IN THE TREATMENT OF CONDITIONS ASSOCIATED WITH CFTR DYSFUNCTION ALGIPHARMA AS (NO) 2018-01-31 EP claimed
EP-3231444-A1 NEW TREATMENT Verona Pharma PLC (GB) 2017-10-18 EP claimed
US-20170112839-A1 NEW TREATMENT VERONA PHARMA LIMITED (GB) 2017-04-27 US claimed
WO-2017060388-A1 ALGINATE OLIGOMERS FOR THE TREATMENT OR PREVENTION OF MICROBIAL OVERGROWTH IN THE INTESTINAL TRACT ALGIPHARMA AS (NO) 2017-04-13 WO claimed
EP-3142701-A1 NEW TREATMENT Verona Pharma PLC (GB) 2017-03-22 EP claimed
WO-2016151051-A1 USE OF ALGINATE OLIGOMERS AND CFTR MODULATORS IN THE TREATMENT OF CONDITIONS ASSOCIATED WITH CFTR DYSFUNCTION ALGIPHARMA AS (NO) 2016-09-29 WO claimed
WO-2015173551-A1 NEW TREATMENT VERONA PHARMA PLC (GB) 2015-11-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210106585-A1 NEW TREATMENT CFTR, LTC4S, FDPS HPGD 1214/4885MAPT 4754/4885ALOX15 501/4885
US-11759467-B2 Treatment CFTR, LTC4S, FPR1 HPGD 1498/4885MAPT 4726/4885ALOX15 633/4885
US-20170112839-A1 NEW TREATMENT CFTR, LTC4S, FDPS HPGD 1214/4885MAPT 4754/4885ALOX15 501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.