Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PARL | Q9H300 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15581083 | 0.75 | ALDH1A1 (0.47) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL9632134 | 0.72 | LMNA (0.53) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL29021266 | 0.71 | CHRM2 (0.39) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL7933823 | 0.71 | ALDH1A1 (0.43) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL40439 | 0.71 | ALDH1A1 (0.53) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL22207807 | 0.69 | ALDH1A1 (0.46) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL6319092 | 0.68 | LMNA (0.52) | ALDH1A1PKMKMT2ASLC1A2ATM | |
| SCHEMBL6929886 | 0.67 | ALDH1A1 (0.43) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL29000169 | 0.66 | KMT2A (0.50) | ALDH1A1PKMCHRM2CHRM4CHRM5 | |
| SCHEMBL7933681 | 0.65 | ALDH1A1 (0.42) | ALDH1A1PKMCHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664392-B2 | Pyrazine derivatives for bioconjugation | Medibeacon, LLC (US) | 2014-03-04 | — | — | US | disclosed |
| US-20120134930-A1 | Pyrazine Derivatives for Bioconjugation | MALLINCKRODT LLC (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120134930-A1 | Pyrazine Derivatives for Bioconjugation | PRXL2A, F12, ANXA5 | ALDH1A1 104/4885PKM 1213/4885CHRM2 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.