SCHEMBL9609810

SCHEMBL9609810

Cc1ccc(Oc2ccnc(Cl)c2)c2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.38
PDGFRB P09619 1/20 0.38
PDGFRA P16234 1/20 0.38
ESRRA P11474 1/20 0.35
TRPA1 O75762 2/20 0.34
AR P10275 1/20 0.34
EGFR P00533 1/20 0.34
S1PR1 P21453 1/20 0.34
LMNA P02545 2/20 0.33
MAPT P10636 2/20 0.33
HTT P42858 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
SCN5A Q14524 1/20 0.33
SCN9A Q15858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL535774 0.82 IDO1 (0.44) CYP1A2PDGFRBPDGFRATRPA1LMNA
SCHEMBL191864 0.79 HPGD (0.46) ESRRATRPA1LMNAMAPTHTT
SCHEMBL28658231 0.78 ESRRA (0.37) PDGFRBPDGFRAESRRALMNAMAPT
SCHEMBL15485154 0.78 MAPK14 (0.46)
SCHEMBL17014137 0.77 RECQL (0.41) CYP1A2LMNAMAPTHTTCYP2C19
SCHEMBL11057427 0.77 S1PR1 (0.34) PDGFRBPDGFRAS1PR1SCN5ASCN9A
SCHEMBL15490439 0.77 SMN1; SMN2 (0.41) CYP1A2ESRRALMNAMAPTHTT
SCHEMBL28928319 0.76 KDR (0.40) PDGFRAESRRALMNA
SCHEMBL190585 0.75 ALDH1A1 (0.53) PDGFRBPDGFRAARHTT
SCHEMBL12695281 0.75 MCL1 (0.36) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180086741-A1 KINASE INHIBITORS OXULAR ACQUISITIONS LIMITED (GB) 2018-03-29 US disclosed
US-20180000830-A1 INHIBITORS OF HEMOPOIETIC CELL KINASE (P-59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION RESPIVERT LIMITED (GB) 2018-01-04 US disclosed
US-9850233-B2 Kinase inhibitors RESPIVERT LIMITED (GB) 2017-12-26 US disclosed
US-9701670-B2 Pyrazolyl-ureas as kinase inhibitors RESPIVERT LIMITED (GB) 2017-07-11 US disclosed
US-20160318909-A1 KINASE INHIBITORS OXULAR ACQUISITIONS LIMITED (GB) 2016-11-03 US disclosed
US-20160115152-A1 Novel Compounds RESPIVERT LTD. (GB) 2016-04-28 US disclosed
US-20160045512-A1 Inhibitors of Hemopoietic Cell Kinase (P59-HCK) and Their Use in the Treatment of Influenza Infection RESPIVERT LIMITED (GB) 2016-02-18 US disclosed
US-9260410-B2 P38 MAP kinase inhibitors RESPIVERT LTD. (GB) 2016-02-16 US disclosed
US-9242960-B2 P38MAP kinase inhibitors Respivert, Ltd. (GB) 2016-01-26 US disclosed
US-20160016934-A1 KINASE INHIBITORS TOPIVERT PHARMA LIMITED (GB) 2016-01-21 US disclosed
US-20140228410-A1 P38MAP KINASE INHIBITORS RESPIVERT LTD. (GB) 2014-08-14 US disclosed
US-20140057915-A1 KINASE INHIBITORS TOPIVERT PHARMA LIMITED (GB) 2014-02-27 US disclosed
US-8642773-B2 P38MAP kinase inhibitor RESPIVERT LTD. (GB) 2014-02-04 US disclosed
US-20130040995-A1 NOVEL COMPOUNDS RESPIVERT LTD. (GB) 2013-02-14 US disclosed
US-8299073-B2 P38 MAP kinase inhibitors RESPIVERT LTD. (GB) 2012-10-30 US disclosed
US-8299074-B2 P38 MAP kinase inhibitors RESPIVERT LTD. (GB) 2012-10-30 US disclosed
US-20120244120-A1 INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION RESPIVERT LTD. (GB) 2012-09-27 US disclosed
US-20120136031-A1 P38MAP KINASE INHIBITOR RESPIVERT LTD. (GB) 2012-05-31 US disclosed
US-20110312963-A1 P38 MAP KINASE INHIBITORS RESPIVERT LTD (GB) 2011-12-22 US disclosed
US-20110294812-A1 P38 MAP KINASE INHIBITORS RESPIVERT LTD. (GB) 2011-12-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312963-A1 P38 MAP KINASE INHIBITORS MAPKAPK2, MAPK1, MAPKAPK3 CYP1A2 1349/4885PDGFRB 825/4885PDGFRA 1494/4885
US-20180086741-A1 KINASE INHIBITORS SYK, BTK, SRC CYP1A2 1761/4885PDGFRB 519/4885PDGFRA 688/4885
US-20180000830-A1 INHIBITORS OF HEMOPOIETIC CELL KINASE (P-59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION HCK, CDK9, PHKG1 CYP1A2 3677/4885PDGFRB 1827/4885PDGFRA 1852/4885
US-20160016934-A1 KINASE INHIBITORS SYK, LYN, BTK CYP1A2 1402/4885PDGFRB 274/4885PDGFRA 307/4885
US-20160318909-A1 KINASE INHIBITORS SYK, LYN, BTK CYP1A2 1372/4885PDGFRB 302/4885PDGFRA 335/4885
US-20160115152-A1 Novel Compounds ESRRA, ESRRB, LTB4R CYP1A2 235/4885PDGFRB 1503/4885PDGFRA 1456/4885
US-20120244120-A1 INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION HCK, CDK9, TTK CYP1A2 3288/4885PDGFRB 2004/4885PDGFRA 1866/4885
US-20140228410-A1 P38MAP KINASE INHIBITORS MAPK1, MAP3K1, MAP3K11 CYP1A2 862/4885PDGFRB 1428/4885PDGFRA 1859/4885
US-20110294812-A1 P38 MAP KINASE INHIBITORS MAPK1, MAP3K1, MAPK3 CYP1A2 1001/4885PDGFRB 1005/4885PDGFRA 1396/4885
US-20130040995-A1 NOVEL COMPOUNDS ESRRA, ESRRB, LTB4R CYP1A2 235/4885PDGFRB 1503/4885PDGFRA 1456/4885
US-20140057915-A1 KINASE INHIBITORS SYK, BTK, LYN CYP1A2 2533/4885PDGFRB 432/4885PDGFRA 503/4885
US-20160045512-A1 Inhibitors of Hemopoietic Cell Kinase (P59-HCK) and Their Use in the Treatment of Influenza Infection HCK, CDK9, TTK CYP1A2 3288/4885PDGFRB 2004/4885PDGFRA 1866/4885
US-20120136031-A1 P38MAP KINASE INHIBITOR MAPK1, MAP3K1, MAP3K11 CYP1A2 847/4885PDGFRB 1490/4885PDGFRA 1921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.