Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.62 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.62 |
| ▸ | PPIA | P62937 | 1/20 | 0.62 |
| ▸ | PPID | Q08752 | 1/20 | 0.62 |
| ▸ | PTPN7 | P35236 | 10/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 5/20 | 0.61 |
| ▸ | BLM | P54132 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.61 |
| ▸ | CASP1 | P29466 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613330 | 0.95 | TDP1 (0.62) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613308 | 0.77 | TDP1 (1.00) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL13856682 | 0.77 | PTPN7 (1.00) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613384 | 0.75 | IKBKB (1.00) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613368 | 0.74 | PTPN7 (1.00) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613319 | 0.73 | IKBKB (0.83) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613317 | 0.71 | KDM4D (0.82) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613300 | 0.71 | IKBKB (0.74) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL9613359 | 0.70 | PTPN7 (0.77) | TDP1HSPD1HSPE1PPIAPPID | |
| SCHEMBL29082759 | 0.70 | PDK1 (0.59) | MEN1POLBKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353094-B2 | Substituted quinoxalines as kinase inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM | 2015-10-01 | — | — | US | disclosed |
| US-8993758-B2 | Substituted quinoxalines and uses thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2013-10-31 | — | — | US | disclosed |
| WO-2012071414-A2 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | TDP1 3381/4885HSPD1 1050/4885HSPE1 762/4885 |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | TDP1 3381/4885HSPD1 1050/4885HSPE1 762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.