Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.56 |
| ▸ | ESRRG | P62508 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ESRRB | O95718 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL961596 | 0.85 | ESRRG (0.57) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13226379 | 0.85 | MAPT (0.59) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL11052376 | 0.83 | ESRRG (0.70) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL963723 | 0.80 | HDAC1 (0.61) | MAPTALDH1A1KDM4EHTTPOLB | |
| SCHEMBL1477967 | 0.80 | MAPT (0.54) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3058851 | 0.80 | KMT2A (0.69) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL61950 | 0.79 | ALDH1A1 (0.58) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1306139 | 0.79 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3680858 | 0.79 | KMT2A (0.71) | MAPTMEN1KMT2AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL3855035 | 0.78 | MAPT (0.53) | MAPTMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060189825-A1 | Ligands for estrogen related receptors and methods for synthesis of said ligands | CITY OF HOPE | 2006-08-24 | — | — | US | claimed |
| US-10906890-B2 | Triazole phenyl compounds as agonists of the APJ receptor | AMGEN INC. (US) | 2021-02-02 | — | — | US | disclosed |
| EP-3541810-B1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20190284173-A1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2019-09-19 | — | — | US | disclosed |
| US-9085550-B2 | Ligands for estrogen related receptors and methods for synthesis of said ligands | CITY OF HOPE (US) | 2015-07-21 | — | — | US | disclosed |
| EP-2248833-B1 | MODIFIED DIENE RUBBER, METHOD FOR PRODUCING THE SAME, RUBBER COMPOSITION USING THE SAME, AND TIRE | BRIDGESTONE CORP (JP) | 2014-03-26 | — | — | EP | disclosed |
| US-20130131340-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | FORMAN BARRY (US) | 2013-05-23 | — | — | US | disclosed |
| US-8389641-B2 | Modified diene rubber, production method thereof, and rubber composition and tire using the rubber | BRIDGESTONE CORPORATION (JP) | 2013-03-05 | — | — | US | disclosed |
| US-20110003911-A1 | MODIFIED DIENE RUBBER, PRODUCTION METHOD THEREOF, AND RUBBER COMPOSITION AND TIRE USING THE RUBBER | BRIDGESTONE CORPORATION (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-2248833-A1 | MODIFIED DIENE RUBBER, METHOD FOR PRODUCING THE SAME, RUBBER COMPOSITION USING THE SAME, AND TIRE | Bridgestone Corporation (JP) | 2010-11-10 | — | — | EP | disclosed |
| US-20100249336-A1 | MODIFIED NATURAL RUBBER AND METHOD FOR PRODUCING SAME, AND RUBBER COMPOSITION AND TIRE USING SUCH A MODIFIED NATURAL RUBBER | BRIDGESTONE CORPORATION (JP) | 2010-09-30 | — | — | US | disclosed |
| CN-101842393-A | Modified natural rubber, process for producing the same, rubber composition and tire using the same | BRIDGESTONE CORP | 2010-09-22 | — | — | CN | disclosed |
| EP-2206730-A1 | MODIFIED NATURAL RUBBER, PROCESS FOR PRODUCTION OF THE SAME, AND RUBBER COMPOSITION AND TIRE EACH COMPRISING THE SAME | Bridgestone Corporation (JP) | 2010-07-14 | — | — | EP | disclosed |
| US-20090318693-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | FORMAN BARRY | 2009-12-24 | — | — | US | disclosed |
| US-7544838-B2 | Ligands for estrogen related receptors and methods for synthesis of said ligands | CITY OF HOPE (US) | 2009-06-09 | — | — | US | disclosed |
| US-20060189825-A1 | Ligands for estrogen related receptors and methods for synthesis of said ligands | CITY OF HOPE | 2006-08-24 | — | — | US | disclosed |
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| US-20030158237-A1 | Combination of antioxidant substances for the treatment of alzheimer's disease | COLBA R & D INC. (CA) | 2003-08-21 | — | — | US | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284173-A1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AGTR1, AGTR2, TBXA2R | MAPT 3966/4885MEN1 4636/4885KMT2A 3930/4885 |
| US-20130131340-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | ESRRA, ESRRB, ESR2 | MAPT 4297/4885MEN1 4346/4885KMT2A 1373/4885 |
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | MAPT 3318/4885MEN1 4329/4885KMT2A 875/4885 |
| US-10906890-B2 | Triazole phenyl compounds as agonists of the APJ receptor | AGTR1, AGTR2, TBXA2R | MAPT 3966/4885MEN1 4636/4885KMT2A 3930/4885 |
| US-20060189825-A1 | Ligands for estrogen related receptors and methods for synthesis of said ligands | ESRRA, ESRRB, ESR2 | MAPT 4297/4885MEN1 4346/4885KMT2A 1373/4885 |
| US-20090318693-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | ESRRA, ESRRB, ESR2 | MAPT 4297/4885MEN1 4346/4885KMT2A 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.