Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030271 | 0.99 | POLB (0.60) | POLBKDM4ELMNAMAPK1CYP1A2 | |
| SCHEMBL9626893 | 0.88 | POLB (0.61) | POLBKDM4ELMNAMAPK1CYP1A2 | |
| Hydrochloric Acid SCHEMBL9618972 | 0.85 | ABCB1 (0.67) | ABCB1 | |
| Hydrochloric Acid SCHEMBL2065176 | 0.82 | HPGD (0.58) | KDM4ELMNAMAPK1CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL1702139 | 0.79 | ABCB1 (0.65) | POLBLMNAMAPK1CYP2C19HTT | |
| SCHEMBL30205105 | 0.79 | NPC1 (0.81) | POLBKDM4ELMNAMAPK1CYP1A2 | |
| SCHEMBL3224251 | 0.79 | NPC1 (0.81) | POLBKDM4ELMNAMAPK1CYP1A2 | |
| Water SCHEMBL51537 | 0.78 | ABCB1 (0.64) | POLBLMNAMAPK1CYP2C19HTT | |
| SCHEMBL9856196 | 0.78 | POLB (0.76) | POLBKDM4ELMNAMAPK1CYP1A2 | |
| SCHEMBL2277722 | 0.78 | ABCB1 (0.67) | POLBLMNAMAPK1CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279475-B1 | BENZOPHENONE DERIVATIVES | WARD BLENKINSOP AND COMPANY LIMITED (GB) | 1992-01-15 | — | — | EP | disclosed |
| EP-0279475-A2 | Benzophenone derivatives | WARD BLENKINSOP AND COMPANY LIMITED (GB) | 1988-08-24 | — | — | EP | disclosed |