Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 6/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476115 | 0.94 | PLA2G4B (0.62) | PLA2G4BKDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL9140317 | 0.94 | PLA2G4B (0.62) | PLA2G4BKDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL7484161 | 0.90 | SMN1; SMN2 (0.62) | PLA2G4BKDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL9619334 | 0.89 | PLA2G4B (0.60) | PLA2G4BKDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL10726761 | 0.87 | LTA4H (0.57) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL7279461 | 0.86 | CYP4F2 (0.59) | PLA2G4BLTA4HTP53TSHR | |
| SCHEMBL3801206 | 0.84 | TBXAS1 (0.60) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL13348627 | 0.84 | KDM4E (0.66) | PLA2G4BKDM4ECYP1A2CYP2D6PDE4A | |
| SCHEMBL5555266 | 0.84 | LTA4H (0.57) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL3487193 | 0.84 | DGKA (0.57) | SMN1; SMN2LTA4HTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259707-B1 | HYDROXYBUTENOLIDE DERIVATIVES, PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 1992-01-02 | — | — | EP | disclosed |
| EP-0259707-A2 | Hydroxybutenolide derivatives, production and use thereof | Takeda Chemical Industries, Ltd. (JP) | 1988-03-16 | — | — | EP | disclosed |