Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 14/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 12/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 12/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.44 |
| ▸ | CFB | P00751 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11134113 | 0.86 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| Hydrochloric Acid SCHEMBL11293311 | 0.85 | ADRA2A (0.36) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL11405247 | 0.74 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL8674172 | 0.69 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AKCNN4 | |
| SCHEMBL3751385 | 0.69 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| Hydrochloric Acid SCHEMBL8674349 | 0.68 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CADRA1AKCNN4 | |
| SCHEMBL1852745 | 0.67 | CFB (0.49) | ADRA2AADRA2BADRA2CADRA1ACFB | |
| SCHEMBL11421926 | 0.67 | LMNA (0.45) | ADRA2AADRA2BADRA2CTAAR1CYP1A2 | |
| SCHEMBL6054462 | 0.66 | NISCH (0.69) | ADRA2AADRA2BADRA2CADRA1ANISCH | |
| SCHEMBL11420042 | 0.66 | POLB (0.50) | TAAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254777-B1 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1992-03-04 | — | — | EP | claimed |
| EP-0212783-B1 | USE OF IMIDAZOLINYLAMINOISOINDOLINES AND RELATED COMPOUNDS IN THE TREATMENT OF HYPERGLYCAEMIA | BEECHAM GROUP PLC (GB) | 1992-01-08 | — | — | EP | claimed |
| EP-0254777-A2 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1988-02-03 | — | — | EP | claimed |
| EP-0212783-A2 | Use of imidazolinylaminoisoindolines and related compounds in the treatment of hyperglycaemia | BEECHAM GROUP PLC (GB) | 1987-03-04 | — | — | EP | claimed |
| EP-0254777-B1 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1992-03-04 | — | — | EP | disclosed |
| US-4221798-A | Hypotensive 2-heterocycloamino-imidazolines | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1980-09-09 | — | — | US | disclosed |