Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 10/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NT5C2 | P49902 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL536913 | 0.79 | BRAF (0.72) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL29475418 | 0.79 | BRAF (0.72) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL9621683 | 0.79 | MAOA (0.40) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL22118772 | 0.77 | BRD4 (0.68) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL13656142 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL28828155 | 0.77 | BRD4 (0.59) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL17372617 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL5437612 | 0.76 | BRD4 (0.62) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL8720615 | 0.75 | BRD4 (0.58) | SMN1; SMN2BRD4NPC1RAB9ATP53 | |
| SCHEMBL17362837 | 0.75 | BRD4 (0.58) | SMN1; SMN2BRD4NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186454-B1 | 6-PURINYL N-(2-CHLOROETHYL) CARBAMATE AND THIOCARBAMATE, A PROCESS FOR THEIR PREPARATION AND USE THEREOF | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1992-04-08 | — | — | EP | disclosed |
| EP-0186454-A2 | 6-Purinyl N-(2-chloroethyl) carbamate and thiocarbamate, a process for their preparation and use thereof | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) | 1986-07-02 | — | — | EP | disclosed |