Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704902 | 0.85 | KMT2A (0.61) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL8889074 | 0.80 | KMT2A (0.80) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL10752717 | 0.80 | KDM4E (0.46) | KMT2AALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL866626 | 0.79 | NR3C1 (0.46) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL220059 | 0.79 | KMT2A (0.72) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL9624375 | 0.79 | KMT2A (0.67) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL9657509 | 0.78 | KMT2A (0.54) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL194730 | 0.78 | PTPN1 (0.53) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1638701 | 0.78 | ALDH1A1 (0.62) | KMT2AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL8006673 | 0.77 | KMT2A (0.65) | KMT2AALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |