Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624575 | 0.88 | CES2 (0.35) | MAPTHCN4MEN1ALDH1A1KMT2A | |
| SCHEMBL9625050 | 0.85 | CYP2D6 (0.33) | MAPTHCN4CYP2D6SCN1ASCN2A | |
| SCHEMBL9623746 | 0.84 | HCN4 (0.46) | MAPTHCN4MEN1ALDH1A1PKM | |
| SCHEMBL9624420 | 0.84 | ALDH1A1 (0.36) | MAPTCYP2D6ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9624609 | 0.83 | ADAM17 (0.34) | SMPD1 | |
| SCHEMBL9624906 | 0.82 | MAPT (0.32) | MAPTHCN4CYP2D6SCN1ASCN2A | |
| SCHEMBL9623908 | 0.81 | MEN1 (0.33) | MAPTHCN4CYP2D6SCN1ASCN2A | |
| SCHEMBL9624619 | 0.80 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL9625241 | 0.80 | ALDH1A1 (0.36) | MAPTCYP2D6ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9625345 | 0.80 | CYP2D6 (0.32) | MAPTHCN4CYP2D6SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |