Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625026 | 0.88 | ADAM17 (0.35) | ADAM17DRD2HTR2BSMN1; SMN2L3MBTL1 | |
| SCHEMBL10666142 | 0.86 | DRD1 (0.36) | DRD2HTR2BDRD1DRD3 | |
| SCHEMBL9624318 | 0.85 | MAPT (0.44) | ADAM17DRD2HTR2BSMPD1SMN1; SMN2 | |
| SCHEMBL9624347 | 0.83 | DRD2 (0.38) | DRD2DRD3 | |
| SCHEMBL9624420 | 0.83 | ALDH1A1 (0.36) | SMPD1SMN1; SMN2 | |
| SCHEMBL9624911 | 0.83 | MAPT (0.32) | SMPD1 | |
| SCHEMBL9625131 | 0.81 | SIGMAR1 (0.35) | SMPD1 | |
| SCHEMBL9624914 | 0.81 | SIGMAR1 (0.34) | DRD2HTR2BSMPD1DRD1DRD3 | |
| SCHEMBL9623969 | 0.79 | GNRHR (0.47) | — | |
| SCHEMBL9625241 | 0.79 | ALDH1A1 (0.36) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |