Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 4/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9625494 | 0.82 | KDM4E (0.46) | KDM4ERIPK1ALDH1A1TAAR1HPGD | |
| Oxalic Acid SCHEMBL9626820 | 0.77 | HPGD (0.38) | KDM4ERIPK1KIF11HPGDBLM | |
| Oxalic Acid SCHEMBL9625360 | 0.77 | RIPK1 (0.39) | KDM4ERIPK1ALDH1A1KIF11HPGD | |
| Oxalic Acid SCHEMBL9625536 | 0.77 | FFAR1 (0.37) | KDM4ERIPK1ALDH1A1KIF11HPGD | |
| Oxalic Acid SCHEMBL9625441 | 0.77 | DPP4 (0.44) | KDM4EALDH1A1KIF11MMP2MMP8 | |
| SCHEMBL5394972 | 0.77 | PPARG (0.49) | KDM4ERIPK1HPGDBLMCTBP2 | |
| SCHEMBL3832104 | 0.77 | KCNN4 (0.48) | KDM4ERIPK1ALDH1A1HPGDBLM | |
| SCHEMBL9875291 | 0.76 | FAAH (0.54) | RIPK1HPGDKMT2A | |
| Oxalic Acid SCHEMBL9624956 | 0.75 | BLM (0.35) | KDM4ERIPK1ALDH1A1KIF11HPGD | |
| SCHEMBL9626513 | 0.73 | RIPK1 (0.47) | KDM4ERIPK1HPGDBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322391-B1 | NEW PHENYLALKYLAMINE DERIVATIVES | AKTIEBOLAGET ASTRA (SE) | 1992-03-25 | — | — | EP | disclosed |
| EP-0322391-A1 | New phenylalkylamine derivatives | AKTIEBOLAGET ASTRA (SE) | 1989-06-28 | — | — | EP | disclosed |