Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10582270 | 1.00 | RIPK1 (0.43) | RIPK1KDM4EHPGDMAPTRAB9A | |
| SCHEMBL16740573 | 0.79 | THRA (0.47) | RIPK1KDM4EHPGDMAPTTDP1 | |
| SCHEMBL9625597 | 0.76 | RIPK1 (0.47) | RIPK1KDM4EPOLBALDH1A1 | |
| SCHEMBL9625594 | 0.76 | RIPK1 (0.47) | RIPK1KDM4EPOLBALDH1A1 | |
| SCHEMBL9626513 | 0.74 | RIPK1 (0.47) | RIPK1KDM4EHPGDTDP1POLB | |
| SCHEMBL5394972 | 0.74 | PPARG (0.49) | RIPK1KDM4EHPGDMAPTTDP1 | |
| SCHEMBL3832104 | 0.74 | KCNN4 (0.48) | RIPK1KDM4EHPGDTDP1POLB | |
| SCHEMBL5381952 | 0.74 | MMP8 (0.47) | RIPK1KDM4EHPGDMAPTRAB9A | |
| SCHEMBL20432396 | 0.72 | RIPK1 (0.38) | RIPK1KDM4EHPGDTDP1PPARG | |
| SCHEMBL9875291 | 0.71 | FAAH (0.54) | RIPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322391-B1 | NEW PHENYLALKYLAMINE DERIVATIVES | AKTIEBOLAGET ASTRA (SE) | 1992-03-25 | — | — | EP | disclosed |
| EP-0322391-A1 | New phenylalkylamine derivatives | AKTIEBOLAGET ASTRA (SE) | 1989-06-28 | — | — | EP | disclosed |