Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136867 | 0.91 | THRB (0.55) | THRATHRBHPGDKDM4EALDH1A1 | |
| SCHEMBL8161806 | 0.83 | THRA (0.47) | THRATHRBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL16740674 | 0.83 | TGM2 (0.47) | THRATHRBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL11092024 | 0.82 | CYP3A4 (0.58) | THRATHRBRIPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9422511 | 0.81 | THRB (0.54) | THRATHRBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL16740537 | 0.80 | ALDH1A1 (0.47) | THRATHRBSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL9625600 | 0.79 | RIPK1 (0.43) | THRATHRBRIPK1HPGDKDM4E | |
| SCHEMBL10582270 | 0.79 | RIPK1 (0.43) | THRATHRBRIPK1HPGDKDM4E | |
| SCHEMBL3832104 | 0.78 | KCNN4 (0.48) | RIPK1HPGDKDM4EALDH1A1DPP4 | |
| SCHEMBL9626513 | 0.78 | RIPK1 (0.47) | RIPK1SMN1; SMN2HPGDKDM4EDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146636-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE | DREXEL UNIVERSITY (US) | 2020-07-16 | — | — | WO | disclosed |
| WO-2015075051-A1 | ALLOSTERIC INHIBITORS OF ATYPICAL PROTEIN KINASES C | UNIVERSITAET DES SAARLANDES (DE) | 2015-05-28 | — | — | WO | disclosed |