Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6455621 | 0.77 | PGR (0.40) | DAOPARP1CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL9860639 | 0.76 | CMA1 (0.40) | SMN1; SMN2ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL8597048 | 0.75 | ALDH1A1 (0.43) | RXRARXRBRXRGDAOPARP1 | |
| SCHEMBL3176733 | 0.74 | RXRA (0.54) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL21974801 | 0.73 | SRD5A1 (0.40) | DAOPARP1NPSR1CYP1A2CYP2A6 | |
| SCHEMBL9625878 | 0.73 | RARB (0.37) | RXRACYP26A1NPSR1CYP1A2CYP2A6 | |
| SCHEMBL8460070 | 0.72 | RXRA (0.49) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL10452858 | 0.72 | PDK2 (0.41) | ALDH1A1L3MBTL1NPC1RAB9AHPGD | |
| SCHEMBL3794002 | 0.72 | PARP1 (0.51) | DAOPARP1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3799866 | 0.72 | PARP1 (0.48) | DAOPARP1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339521-B1 | PROCESS FOR MANUFACTURING TETRALIN DERIVATIVES, AND TETRALIN DERIVATIVES | BASF Aktiengesellschaft (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4950369-A | Preparation of tetralin derivatives, and novel tetralin derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1990-08-21 | — | — | US | disclosed |
| EP-0339521-A1 | Process for manufacturing tetralin derivatives, and tetralin derivatives | BASF Aktiengesellschaft (DE) | 1989-11-02 | — | — | EP | disclosed |