Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 14/20 | 0.56 |
| ▸ | PPARG | P37231 | 13/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 13/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206775 | 0.90 | PPARD (0.69) | PPARDPPARGFFAR1PPARA | |
| SCHEMBL9669326 | 0.86 | HTR1A (0.58) | PPARDPPARGFFAR1ATM | |
| SCHEMBL24090506 | 0.82 | HTR2B (0.55) | — | |
| SCHEMBL3652699 | 0.82 | MTNR1A (0.54) | — | |
| SCHEMBL134401 | 0.81 | HTR1A (0.43) | PPARDPPARGFFAR1 | |
| SCHEMBL9627798 | 0.81 | HTR1A (0.50) | — | |
| SCHEMBL9629898 | 0.79 | MTNR1A (0.56) | — | |
| SCHEMBL132847 | 0.79 | MTNR1A (0.66) | — | |
| SCHEMBL172889 | 0.78 | HTR1A (0.57) | — | |
| SCHEMBL2691621 | 0.78 | PPARD (0.54) | PPARDPPARGFFAR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-B1 | 3-AMINOMETHYL DERIVATIVES OF INDANE, INDOLINE AND DIHYDROBENZOFURANE AND DIHYDROBENZOTHIOPHENE | H. LUNDBECK A/S (DK) | 1992-05-06 | — | — | EP | disclosed |
| US-4946863-A | CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith | H. LUNDBECK A/S (DK) | 1990-08-07 | — | — | US | disclosed |
| US-4847254-A | CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes | H. LUNDBECK A/S (DK) | 1989-07-11 | — | — | US | disclosed |
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |