Benzoic Acid

Benzoic Acid

SCHEMBL9628348

C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@]13CC[C@]2(O)CC3.O=C(O)c1ccccc1.O=C(O)c1ccccc1

nearest known ligand 0.47

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Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STS P08842 11/20 0.47
HSD17B1 P14061 4/20 0.47
CYP3A4 P08684 4/20 0.47
ESR1 P03372 3/20 0.47
MAPT P10636 3/20 0.47
LMNA P02545 3/20 0.47
HIF1A Q16665 3/20 0.47
SHBG P04278 2/20 0.47
CYP1A2 P05177 2/20 0.47
HSD17B10 Q99714 2/20 0.47
AKR1B10 O60218 1/20 0.47
PGR P06401 1/20 0.47
SERPINA6 P08185 1/20 0.47
AR P10275 1/20 0.47
CYP19A1 P11511 1/20 0.47
AKR1B1 P15121 1/20 0.47
NFKB1 P19838 1/20 0.47
SLC6A4 P31645 1/20 0.47
OPRM1 P35372 1/20 0.47
SNCA P37840 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL514373 0.89 ESR1 (0.53) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL29500480 0.89 ESR1 (0.53) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL8959369 0.89 ESR1 (0.53) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL8938727 0.85 SHBG (0.50) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL9628223 0.77 LMNA (0.57) STSHSD17B1CYP3A4ESR1MAPT
Estrone SCHEMBL1270201 0.76 CYP19A1 (0.81) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL9627672 0.76 LMNA (0.55) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL9627476 0.76 LMNA (0.51) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL8959358 0.75 ESR1 (0.57) STSHSD17B1CYP3A4ESR1MAPT
SCHEMBL9627648 0.75 MAPT (0.59) STSHSD17B1CYP3A4ESR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0318490-B1 14,17-G(B)-ETHANO-14-G(B)-ESTRATRIENES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE SCHERING AKTIENGESELLSCHAFT (DE) 1992-01-29 EP claimed
EP-0318490-B1 14,17-G(B)-ETHANO-14-G(B)-ESTRATRIENES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE SCHERING AKTIENGESELLSCHAFT (DE) 1992-01-29 EP disclosed