Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629404 | 0.86 | TRPM8 (0.59) | TRPM8CDC7DBF4ALOX5 | |
| SCHEMBL14840398 | 0.84 | CDC7 (0.55) | TRPM8CDC7DBF4ALOX5MAPT | |
| SCHEMBL9630543 | 0.83 | TRPM8 (0.57) | TRPM8L3MBTL1CDC7DBF4ALOX5 | |
| SCHEMBL1458929 | 0.82 | ALOX5 (0.60) | TRPM8CDC7DBF4ALOX5MAPT | |
| SCHEMBL9630221 | 0.81 | TRPM8 (0.54) | TRPM8CDC7DBF4ALOX5PTGDR2 | |
| SCHEMBL11466220 | 0.80 | ALDH1A1 (0.67) | L3MBTL1PTGDR2MAPT | |
| SCHEMBL6840453 | 0.80 | L3MBTL1 (0.55) | TRPM8L3MBTL1PTGDR2MAPT | |
| SCHEMBL18015850 | 0.80 | L3MBTL1 (0.55) | TRPM8L3MBTL1PTGDR2MAPT | |
| SCHEMBL6603517 | 0.79 | L3MBTL1 (0.58) | TRPM8L3MBTL1CDC7DBF4PTGDR2 | |
| SCHEMBL26141800 | 0.79 | L3MBTL1 (0.54) | TRPM8L3MBTL1ALOX5PTGDR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A4 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |