Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630543 | 0.90 | TRPM8 (0.57) | TRPM8ALOX5CDC7DBF4 | |
| SCHEMBL9628554 | 0.86 | TRPM8 (0.62) | TRPM8ALOX5CDC7DBF4 | |
| SCHEMBL9630221 | 0.85 | TRPM8 (0.54) | TRPM8ALOX5CDC7DBF4 | |
| SCHEMBL7693031 | 0.81 | ALOX5 (0.57) | ALOX5 | |
| SCHEMBL9629413 | 0.75 | ALOX5 (0.75) | TRPM8ALOX5 | |
| SCHEMBL9754290 | 0.74 | ALOX5 (0.54) | TRPM8ALOX5CDC7DBF4 | |
| SCHEMBL9630604 | 0.73 | ALOX5 (0.72) | TRPM8ALOX5 | |
| SCHEMBL9629560 | 0.73 | TRPM8 (0.66) | TRPM8CDC7DBF4 | |
| SCHEMBL9630548 | 0.73 | ALOX5 (0.62) | ALOX5 | |
| SCHEMBL1954805 | 0.72 | ALOX5 (0.56) | TRPM8ALOX5CDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |