Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL962180 | 0.86 | ASAH1 (0.35) | ALDH1A1NPC1RAB9ASMN1; SMN2RECQL | |
| Potassium Ion SCHEMBL966080 | 0.83 | ALDH1A1 (0.34) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL964029 | 0.83 | PPARG (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL964030 | 0.83 | PPARG (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2CNR2 | |
| Potassium Ion SCHEMBL963263 | 0.82 | NPC1 (0.31) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| Potassium Ion SCHEMBL963147 | 0.80 | NOTUM (0.33) | ALDH1A1NPC1RAB9ASMN1; SMN2CNR2 | |
| Potassium Ion SCHEMBL967647 | 0.79 | CNR2 (0.35) | ALDH1A1NPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL965896 | 0.77 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL965897 | 0.77 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL964447 | 0.77 | NPC1 (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | PPARA, PPARD, PPARG | ALDH1A1 821/4885NPC1 1538/4885RAB9A 2322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.