Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9632136 | 0.91 | PDE10A (0.54) | PDE10AGPBAR1CYSLTR1CYSLTR2ADAMTS4 | |
| SCHEMBL9630556 | 0.83 | MEN1 (0.65) | PDE10AGPBAR1CYSLTR1CYSLTR2ADAMTS4 | |
| SCHEMBL9632872 | 0.75 | PDE10A (0.48) | PDE10AGPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL7008427 | 0.74 | GPBAR1 (0.64) | PDE10AGPBAR1CYSLTR1CYSLTR2MEN1 | |
| SCHEMBL9630717 | 0.74 | PDE10A (0.45) | PDE10AGPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9631884 | 0.74 | PDE10A (0.58) | PDE10AGPBAR1CYSLTR1ALOX5 | |
| SCHEMBL9632132 | 0.73 | ADAMTS4 (0.52) | PDE10AGPBAR1CYSLTR1CYSLTR2ADAMTS4 | |
| SCHEMBL9865885 | 0.73 | GPBAR1 (0.57) | PDE10AGPBAR1CYSLTR1CYSLTR2ADAMTS4 | |
| SCHEMBL9866291 | 0.73 | CYSLTR1 (0.52) | PDE10AGPBAR1CYSLTR1CYSLTR2ADAMTS4 | |
| SCHEMBL9876648 | 0.72 | CYSLTR2 (0.60) | PDE10AGPBAR1CYSLTR1CYSLTR2ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120744-A | For combating diseases susceptible to the action of lipoxygenase inhibitors | BAYER AKTIENGESELLSCHAFT (DE) | 1992-06-09 | — | — | US | disclosed |