Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL22320908 | 1.00 | TDP1 (0.53) | TDP1TSHRHSD17B10ALDH1A1 | |
| Isopropyl Alcohol SCHEMBL28183520 | 0.86 | LMNA (0.38) | TDP1TSHRHSD17B10ALDH1A1 | |
| Isopropyl Alcohol SCHEMBL28165739 | 0.86 | LMNA (0.38) | TDP1TSHRHSD17B10ALDH1A1 | |
| Butanol SCHEMBL9187169 | 0.84 | TSHR (0.53) | TDP1TSHRHSD17B10ALDH1A1 | |
| Alcohol SCHEMBL442255 | 0.80 | ALDH1A1 (0.43) | TSHRALDH1A1 | |
| SCHEMBL8386335 | 0.78 | USP2 (0.39) | TSHRALDH1A1 | |
| SCHEMBL2722071 | 0.78 | HSD17B10 (0.33) | TSHRHSD17B10 | |
| Alcohol SCHEMBL8207886 | 0.77 | ALDH1A1 (0.40) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL9629466 | 0.77 | ALDH1A1 (0.38) | TSHRALDH1A1 | |
| Ethylene Glycol SCHEMBL9630159 | 0.77 | ALDH1A1 (0.38) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5139980-A | Adding a hydrolyzable and condensable metal compound to oxide seed particles having an alkylene glycol bonded to its surface | NIPPON SHOKUBAI KAGAKU KOGYO CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |