Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | FABP2 | P12104 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633 | 0.88 | ALDH1A1 (0.39) | LPAR1LPAR3MAPTMEN1KMT2A | |
| SCHEMBL9972 | 0.80 | LPAR1 (0.39) | PTGS1PGRPDE4ALPAR1LPAR3 | |
| SCHEMBL9632 | 0.78 | ALDH1A1 (0.43) | MAPTHPGDALDH1A1L3MBTL1KDM4E | |
| SCHEMBL27915166 | 0.76 | PTGS2 (0.50) | PTGS1PGRPDE4APTGS2MAPT | |
| SCHEMBL17918662 | 0.74 | PTGS2 (0.70) | PTGS1PGRPDE4APTGS2MAPT | |
| SCHEMBL9555720 | 0.74 | PTGS2 (0.70) | PTGS1PGRPDE4APTGS2MAPT | |
| SCHEMBL31456322 | 0.74 | PTGS2 (0.70) | PTGS1PGRPDE4APTGS2MAPT | |
| SCHEMBL8755060 | 0.74 | PTGS2 (0.70) | PTGS1PGRPDE4APTGS2MAPT | |
| SCHEMBL9974 | 0.71 | LPAR1 (0.40) | LPAR1LPAR3MAPTMEN1KMT2A | |
| SCHEMBL10089 | 0.67 | AKR1C3 (0.42) | PTGS1LPAR1LPAR3PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |