Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.34 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9972 | 0.92 | LPAR1 (0.39) | LPAR1LPAR3MAPTTDP1P2RY12 | |
| SCHEMBL10091 | 0.90 | PTGS2 (0.41) | LPAR1LPAR3MAPTKDM4EALDH1A1 | |
| SCHEMBL9784 | 0.83 | ABCC3 (0.42) | LPAR1MAPTABCC3ABCC4ABCB11 | |
| SCHEMBL10136 | 0.82 | AKT1 (0.42) | LPAR1MAPTTDP1NPSR1ABCC3 | |
| SCHEMBL10089 | 0.82 | AKR1C3 (0.42) | LPAR1LPAR3MAPTHPGDSMN1; SMN2 | |
| SCHEMBL9783 | 0.78 | OPRM1 (0.38) | LPAR1MAPTTDP1NPSR1ABCC3 | |
| SCHEMBL9973 | 0.78 | SYK (0.38) | P2RY12KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL10135 | 0.77 | LMNA (0.39) | LPAR1TDP1NPSR1ABCC3ABCC4 | |
| SCHEMBL9633 | 0.77 | ALDH1A1 (0.39) | LPAR1LPAR3MAPTKDM4ENPC1 | |
| SCHEMBL10449 | 0.77 | LPAR1 (0.46) | LPAR1LPAR3MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |