Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | TTPA | P49638 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10640049 | 0.89 | MEN1 (0.42) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9631986 | 0.88 | TTPA (0.46) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9632317 | 0.84 | PSEN1 (0.40) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10641768 | 0.84 | MEN1 (0.46) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9633318 | 0.83 | CYP3A4 (0.45) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL7487350 | 0.81 | MEN1 (0.52) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10640341 | 0.78 | MEN1 (0.56) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10636293 | 0.76 | TTPA (0.49) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9630985 | 0.75 | MAPT (0.43) | PSEN1MEN1KMT2ATTPAMAPT | |
| SCHEMBL9632130 | 0.75 | PSEN1 (0.44) | PSEN1MEN1KMT2ATTPAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104888-A | Anticholesterol or antidiabetic agents | SANKYO COMPANY, LIMITED (JP) | 1992-04-14 | — | — | US | disclosed |
| EP-0207581-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE | SANKYO COMPANY LIMITED (JP) | 1990-09-12 | — | — | EP | disclosed |
| EP-0207581-A2 | Thiazolidine derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |