Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | TTPA | P49638 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631986 | 0.87 | TTPA (0.46) | PSEN1MAPTKMT2AMEN1MGLL | |
| SCHEMBL9630985 | 0.87 | MAPT (0.43) | PSEN1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL10639032 | 0.83 | KMT2A (0.47) | PSEN1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL9075912 | 0.79 | PSEN1 (0.40) | PSEN1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL9632234 | 0.78 | PSEN1 (0.49) | PSEN1KMT2AMEN1 | |
| SCHEMBL10636293 | 0.76 | TTPA (0.49) | PSEN1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL10641737 | 0.76 | MAPT (0.47) | MAPTKMT2AMEN1TDP1TTPA | |
| SCHEMBL9631048 | 0.75 | MAPT (0.48) | PSEN1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL9631318 | 0.75 | PSEN1 (0.46) | PSEN1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL10642037 | 0.72 | TTPA (0.47) | PSEN1MAPTKMT2AMEN1TTPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104888-A | Anticholesterol or antidiabetic agents | SANKYO COMPANY, LIMITED (JP) | 1992-04-14 | — | — | US | disclosed |
| EP-0207581-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE | SANKYO COMPANY LIMITED (JP) | 1990-09-12 | — | — | EP | disclosed |
| EP-0207581-A2 | Thiazolidine derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |