SCHEMBL9632649

SCHEMBL9632649

Cc1c(C)c2c(c(C)c1OC(OC(C)(C)C)C(=O)O)C(=O)CC(C)(COc1ccc(N)cc1)O2

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.31
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
KMT2A Q03164 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9632908 0.82 DDB1 (0.34) MEN1MAPTKMT2ATDP1
SCHEMBL7125937 0.81 MEN1 (0.36) PPARGMEN1MAPTKMT2ATDP1
SCHEMBL8980246 0.78 MEN1 (0.44) PPARGMEN1MAPTKMT2ATDP1
SCHEMBL10641941 0.72 PPARG (0.39) PPARGMEN1MAPTKMT2ATDP1
SCHEMBL9630982 0.71 KMT2A (0.36) MEN1MAPTKMT2A
SCHEMBL9632620 0.71 MEN1 (0.33) MEN1KMT2A
SCHEMBL8177483 0.70 KMT2A (0.39) MEN1MAPTKMT2A
SCHEMBL10640704 0.69 PPARG (0.46) PPARGMEN1MAPTKMT2ATDP1
SCHEMBL9632055 0.69 KDM4E (0.33) PPARGMEN1MAPTKMT2ATDP1
SCHEMBL9632167 0.69 MEN1 (0.34) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5104888-A Anticholesterol or antidiabetic agents SANKYO COMPANY, LIMITED (JP) 1992-04-14 US disclosed
EP-0207581-B1 THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE SANKYO COMPANY LIMITED (JP) 1990-09-12 EP disclosed
EP-0207581-A2 Thiazolidine derivatives, their preparation and use SANKYO COMPANY LIMITED (JP) 1987-01-07 EP disclosed