Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | UBE2N | P61088 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633601 | 0.89 | POLB (0.60) | TSHRUBE2NPOLBKMT2AUSP2 | |
| SCHEMBL9633286 | 0.88 | TSHR (0.62) | TSHRUBE2NPOLBSMN1; SMN2KMT2A | |
| SCHEMBL9631897 | 0.87 | ALDH1A1 (0.60) | TSHRUBE2NPOLBSMN1; SMN2KMT2A | |
| SCHEMBL9632623 | 0.86 | TSHR (0.69) | TSHRUBE2NPOLBSMN1; SMN2KMT2A | |
| SCHEMBL7662928 | 0.79 | SMN1; SMN2 (0.70) | POLBSMN1; SMN2KMT2AUSP2GAA | |
| SCHEMBL48765 | 0.75 | PKM (0.57) | TSHRKMT2AL3MBTL1GAAMEN1 | |
| SCHEMBL30997420 | 0.75 | CA5A (0.47) | TSHRUBE2NPOLBSMN1; SMN2KMT2A | |
| SCHEMBL4660848 | 0.75 | CA5A (0.47) | TSHRUBE2NPOLBSMN1; SMN2KMT2A | |
| SCHEMBL30610782 | 0.75 | PKM (0.57) | TSHRKMT2AL3MBTL1GAAMEN1 | |
| SCHEMBL9125107 | 0.73 | CA5A (0.48) | TSHRUBE2NSMN1; SMN2KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331943-B1 | PHENOXYETHYLAMINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND COMPOSITION FOR EXHIBITING EXCELLENT ALPHA-1-BLOCKING ACTIVITY CONTAINING THE SAME | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1992-06-17 | — | — | EP | disclosed |
| US-4971990-A | HYPOTENSIVE AGENTS, DYSUREA | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0331943-A1 | Phenoxyethylamine derivatives, process for preparing the same, and composition for exhibiting excellent alpha-1-blocking activity containing the same | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1989-09-13 | — | — | EP | disclosed |