Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.44 |
| ▸ | DGKA | P23743 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 4/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 5/20 | 0.39 |
| ▸ | PPARD | Q03181 | 5/20 | 0.39 |
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425770 | 0.93 | DNM1 (0.46) | LMNADNM1DGKACES2CES1 | |
| SCHEMBL9633231 | 0.89 | MEN1 (0.49) | LMNADNM1DGKACES2CES1 | |
| SCHEMBL9633174 | 0.85 | LMNA (0.41) | LMNADNM1DGKACES2KDM5A | |
| SCHEMBL11542737 | 0.84 | EPHX2 (0.54) | LMNAPPARGPPARDPPARATDP1 | |
| SCHEMBL11542739 | 0.84 | EPHX2 (0.54) | LMNAPPARGPPARDPPARATDP1 | |
| SCHEMBL11694353 | 0.84 | EPHX2 (0.50) | LMNAPPARGPPARDPPARATDP1 | |
| SCHEMBL9633089 | 0.84 | PAOX (0.42) | LMNADNM1CES2KDM5APHF8 | |
| SCHEMBL12640149 | 0.83 | LMNA (0.58) | LMNACES2CES1PPARGPPARD | |
| SCHEMBL12924011 | 0.83 | LMNA (0.58) | LMNACES2CES1PPARGPPARD | |
| SCHEMBL9657056 | 0.83 | LMNA (0.58) | LMNACES2CES1KDM5APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162315-A | Topical administration of diltiazem | THERAPEUTIC PATCH RESEARCH N.V. | 1992-11-10 | — | — | US | disclosed |