Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 6/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.37 |
| ▸ | DGKA | P23743 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633089 | 0.93 | PAOX (0.42) | LMNAKDM5ADNM1PHF8KDM4C | |
| SCHEMBL9633149 | 0.85 | LMNA (0.48) | LMNAKDM5ADNM1PHF8KDM4C | |
| SCHEMBL9633650 | 0.84 | LMNA (0.44) | LMNAKDM5ADNM1PHF8KDM4C | |
| SCHEMBL9633491 | 0.81 | PAOX (0.48) | LMNAKDM5ADNM1PHF8KDM4C | |
| SCHEMBL9633084 | 0.80 | LMNA (0.36) | LMNAKDM5ADNM1PHF8KDM4C | |
| SCHEMBL26799471 | 0.79 | DNM1 (0.47) | KDM5ADNM1PHF8KDM4CPAOX | |
| SCHEMBL9817192 | 0.79 | LMNA (0.48) | LMNAKDM5ADNM1PHF8KDM4C | |
| SCHEMBL9817184 | 0.79 | LMNA (0.48) | LMNAKDM5ADNM1PHF8KDM4C | |
| SCHEMBL3425770 | 0.78 | DNM1 (0.46) | LMNADNM1HDAC11DGKACES2 | |
| SCHEMBL11060933 | 0.77 | EPHX2 (0.51) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162315-A | Topical administration of diltiazem | THERAPEUTIC PATCH RESEARCH N.V. | 1992-11-10 | — | — | US | disclosed |