Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 4/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633174 | 0.93 | LMNA (0.41) | PAOXLMNACES2KDM5ADNM1 | |
| SCHEMBL9633491 | 0.86 | PAOX (0.48) | PAOXS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL9633149 | 0.84 | LMNA (0.48) | LMNACES2KDM5ADNM1HDAC11 | |
| SCHEMBL9633650 | 0.82 | LMNA (0.44) | PAOXLMNAKDM5ADNM1HDAC3 | |
| SCHEMBL9633084 | 0.79 | LMNA (0.36) | LMNAKDM5ADNM1HDAC3HDAC4 | |
| SCHEMBL25321005 | 0.79 | S1PR2 (0.49) | PAOXS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL31271908 | 0.79 | S1PR2 (0.49) | PAOXS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL31272060 | 0.79 | S1PR2 (0.49) | PAOXS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL25318500 | 0.79 | S1PR2 (0.49) | PAOXS1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL31272009 | 0.79 | S1PR2 (0.49) | PAOXS1PR2S1PR4S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162315-A | Topical administration of diltiazem | THERAPEUTIC PATCH RESEARCH N.V. | 1992-11-10 | — | — | US | disclosed |