Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | NQO2 | P16083 | 3/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634237 | 0.87 | MTNR1A (0.43) | PPARAPPARDNQO2TRPV1PLA2G4A | |
| SCHEMBL9634320 | 0.85 | CYP1A2 (0.50) | NQO2MAPTMTNR1AMTNR1B | |
| SCHEMBL9634970 | 0.83 | NQO2 (0.49) | NQO2PLA2G4AMTNR1AMEN1KMT2A | |
| SCHEMBL9633789 | 0.82 | PLA2G4A (0.45) | NQO2PLA2G4AMTNR1AMTNR1B | |
| SCHEMBL9373723 | 0.81 | CPT1A (0.46) | PPARGPLA2G4A | |
| SCHEMBL9633804 | 0.80 | NQO2 (0.48) | NQO2TRPV1PLA2G4AMAPTMTNR1A | |
| SCHEMBL9633886 | 0.80 | MAPT (0.49) | NQO2TRPV1PLA2G4AMAPTMTNR1A | |
| SCHEMBL9373055 | 0.80 | PLA2G4A (0.51) | PLA2G4A | |
| SCHEMBL9633803 | 0.79 | NQO2 (0.48) | NQO2KMT2A | |
| SCHEMBL9633818 | 0.79 | NQO2 (0.42) | NQO2MAPTMTNR1AKMT2AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |